The Forkhead transcription factor FOXA2 plays a fundamental role in controlling metabolic homeostasis in the liver during fasting.The precise molecular regulation of FOXA2 in response to nutrients is not fully understood.Here, we studied whether FOXA2 could be controlled at a post-translational level by acetylation.By means of LC-MS/MS analyses, we
Background: Treatment of recurrent platinum-resistant high grade serous ovarian cancer (HGSOC) remains a challenge.Novel treatment options for recurrent disease are an unmet need.Case: A 69-year-old with recurrent, metastatic, platinum-resistant HGSOC overexpressing TROP2 experienced a significant response to the antibody-drug conjugate (ADC) sacit
Developing high-value crop planting industries according to local conditions is an important strategy for targeted poverty alleviation, and it is also a momentous solution for agricultural structure adjustment.However, previous Toggle studies mainly have focused on their spatiotemporal evolution and economic benefits instead of their environmental
In this paper is introduced a methodology for solving the regulation and tracking control problem in servomechanisms through a Proportional Retarded controller with a Feedforward and Feedback (PR+FF) compensation scheme.The key advantage of this approach is that it enables regulation and tracking control without requiring velocity measurements, whi
Due to the Male Contraceptives importance of increasing the firing precision of self-propelled artillery system corresponding to the projectile impact point, the launch dynamics of self-propelled artillery based on the transfer matrix method for multibody system (MSTMM) is studied in this paper.By using MSTMM to study launch dynamics of self-propel